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Police have fired rubber bullets and tear gas to disperse both foreign nationals and the protesters.
The Mamelodi group that intended to hand over a memorandum to Home Affairs has not reached its destination.
The foreign nationals, who are armed, said they were out to defend themselves.
Police earlier fired stun grenades at anti-migrant protesters outside Home Affairs offices in Pretoria.
There are currently two groups of anti-foreigners protesters in the Pretoria city centre. The Mamelodi group wanted to deliver a memorandum peacefully, but the Atteridgeville crowd would not accept this.
The second group then went on a looting spree in the CBD, prompting police to take action.
The protesters were also lying in the middle of the road daring police to shoot them.
There’s a standoff on Johannes Ramokhoase Street between large groups of the protesters and foreign nationals.
Both groups are armed. The Somalians say they have had enough of the xenophobic attacks.